The Single-Balloon snteroscopy (SBE) System was developed in 2006 and was introduced in 2007. The use of upper and lower gastrointestinal endoscopes has revolutionized the diagnosis and treatment of diseases of the esophagus, stomach, duodenum, and colon (large intestine). The last remaining frontier in the intestines has been the small intestine. Wireless capsule endoscopy allows physicians to visualize the inside of the intestines from the esophagus through to the colon. Capsule endoscopy has limitations, most notably, the inability to control the capsule's passage and to perform therapeutic interventions, such as biopsy and electrocautery.